NOGUCHI Emi (野口　瑛美) , MD,PhD

野口　瑛美’s Story

私は、乳がんと婦人科がんの研究と治療を専門とする腫瘍内科医です。 ホルモン受容体陽性、HER2陰性の転移性乳がんを対象とした、アジアの研究者が開始したランダム化第III相試験（PATHWAY試験、NCT03423199）の研究者および運営委員会のメンバーです。 また、全国協力グループである日本臨床腫瘍研究グループ（JCOG）の積極的なメンバーであり、JCOG乳房研究グループの臨床試験ワーキンググループに所属しています。

研究対象

臨床試験のデザイン、抗がん剤の開発、手頃な価格のがん治療について研究しています。

経歴

2021-現在	国立がん研究センター中央病院　腫瘍内科　医長
2016-2021	国立がん研究センター中央病院　乳腺・腫瘍内科　医員
2014-2016	医薬品医療機器総合機構　新薬審査第5部　Reviewer
2012-2014	国立がん研究センター中央病院　乳腺・腫瘍内科　主任研修医

研究実績

Critical Appraisal of Adjuvant Platinum-Based Chemotherapy for Basal Subtype Triple-Negative Breast Cancer With Residual Disease After Neoadjuvant Chemotherapy.

Shimoi T, Noguchi E, Sudo K, Chua YJ, Yonemori K

• 論文

Hotspot mutation profiles of AKT1 in Asian women with breast and endometrial cancers.

Shimoi T, Hashimoto J, Sudo K, Shimomura A, Noguchi E, Shimizu C, Yunokawa M, Yonemori K, Yoshida H, Yoshida M, Kato T, Kinoshita T, Fukuda T, Fujiwara Y, Tamura K

• 論文

Current status of PD-1/PD-L1 blockade immunotherapy in breast cancer. Jpn J Clin Oncol. 2021;51(3):321-332.

Noguchi E, Shien T, Iwata H

• 論文

Regulatory and Operational Challenges in Conducting Asian International Academic Trial for Expanding the Indications of Cancer Drugs. Clin Transl Sci. 2021;14:1015-1025.

Hata T, Nakamura K, Yonemori K, Noguchi E, Watanabe M, Sohn J, Lu YS, Yap YS, Tamura K, Fuiwara Y

• 論文

Current Status of Advance Care Planning and End-of-life Communication for Patients with Advanced and Metastatic Breast Cancer. Oncologist. 2021;26(4):e686-e693.

Sagara Y, Mori M, Yamamoto S, Eguchi K, Iwatani T, Naito Y, Kogawa T, Tanaka K, Kotani H, Yasojima H, Ozaki Y, Noguchi E, Miyasita M, Kondo N, Niikura N, Toi M, Shien T, Iwata H

• 論文

Efficacy of second-line treatment and prognostic factors in patients with advanced malignant peritoneal mesothelioma: a retrospective study.

Kitadai R, Shimoi T, Sudo K, Noguchi E, Nagata Y, Sawada R, Takashima A, Boku N, Yonemori K

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Impact of ALK Inhibitors in Patients With ALK-Rearranged Nonlung Solid Tumors. JCO Precision Oncology. 2021(5):756-66.

Takeyasu Y, Okuma HS, Kojima Y, Nishikawa T, Tanioka M, Sudo K, Tatsunori Shimoi , Emi Noguchi, Ayumu Arakawa, Taisuke Mori, Kuniko Sunami, Takashi Kubo, Takashi Kohno, Yoshida Akihiko, Noboru Yamamoto, Kan Yonemori, et al.

• 論文

Safety and Evidence of Off-Label Use of Approved Drugs at the National Cancer Center Hospital in Japan. JCO Oncol Pract. 2021;17(3):e416-e425.

Bun S, Yonemori K, Sunadoi H, Nishigaki R, Noguchi E, Okusaka T, Nishida T, Fujiwara Y

• 論文

Safety and Evidence of Off-Label Use of Approved Drugs at the National Cancer Center Hospital in Japan. JCO Oncol Pract. 2021 Mar;17(3):e416-e425

Bun S, Yonemori K, Sunadoi H, Nishigaki R, Noguchi E, Okusaka T, Nishida T, Fujiwara Y

• 論文

Breast Cancer Brain Metastasis-Overview of Disease State, Treatment Options and Future Perspectives

Chikashi Watase, Sho Shiino, Tatsunori Shimoi, Emi Noguchi, Tomoya Kaneda, Yusuke Yamamoto, Kan Yonemori, Shin Takayama, Akihiko Suto

• 論文

Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants. N Engl J Med. 2021;384(1):42-50.

Arakawa A, Ichikawa H, Kubo T, Motoi N, Kumamoto T, Nakajima M, Yonemori K, Noguchi E, Sunami K, Shiraishi K, Kakishima H, Yoshida H, Hishiki T, Kawakubo N, Kuroda T, Kiyokawa T, Yamada K, Yanaihara N, Takahashi K, Okamoto A, et al.

• 論文

Neoadjuvant chemotherapy promotes the expression of HER3 in patients with ovarian cancer. Oncol Lett. 2020 Dec;20(6):336.

Mizuno T, Kojima Y, Yonemori K, Yoshida H, Sugiura Y, Ohtake Y, Okuma HS, Nishikawa T, Tanioka M, Sudo K, Shimomura A, Noguchi E, Kato T, Shimoi T, Uno M, Ishikawa M, Fujiwara Y, Ohe Y, Tamura K

• 論文

Response to Dabrafenib and Trametinib of a Patient with Metaplastic Breast Carcinoma Harboring a BRAF V600E Mutation. Case Rep Oncol Med. 2020;2020:2518383

Seo T, Noguchi E, Yoshida M, Mori T, Tanioka M, Sudo K, Shimomura A, Yonemori K, Fujiwara Y, Tamura K

• 論文

Treatment Outcome of Second-Line Chemotherapy for Gynecologic Carcinosarcoma. Oncology. 2020;98(10):699-705.

Ebata T, Yonemori K, Nishikawa T, Sudo K, Shimomura A, Noguchi E, et al.

• 論文

Systemic treatments in MDM2 positive intimal sarcoma: A multicentre experience with anthracycline, gemcitabine, and pazopanib within the World Sarcoma Network. Cancer. 2020;126(1):98-104.

Frezza AM, Assi T, Lo Vullo S, Ben-Ami E, Dufresne A, Yonemori K, Noguchi E, Siontis B, Ferraro R, Teterycz P, Duffaud F, Ravi V, Vincenzi B, Gelderblom H, Pantaleo MA, Baldi GG, Desar I, Fedenko A, Maki RG, Jones RL, et al.

• 論文

Bone marrow examination in patients with Ewing sarcoma/peripheral primitive neuroectodermal tumor without metastasis based on 18F-fluorodeoxyglucose positron emission tomography/computed tomography.

Inagaki C, Shimoi T, Sumiyoshi Okuma H, Kawachi A, Sudo K, Shimomura A, Noguchi E, Kodaira M, Yunokawa M, Yonemori K, Shimizu C, Arakawa A, Ogawa C, Yoshida A, Fujiwara Y, Tamura K

• 論文

The Incidence of Nonmalignant Diseases among Patients with Suspected Carcinoma of Unknown Primary Site.

Sato J, Shimoi T, Shimomura A, Noguchi E, Kodaira M, Yunokawa M, Yonemori K, Shimizu C, Fujiwara Y, Yoshida M, Tamura K

• 論文

Trastuzumab emtansine plus pertuzumab in Japanese patients with HER2-positive metastatic breast cancer: a phase Ib study. Breast Cancer. 2019;26(1):39-46.

Noguchi E, Tamura K, Hattori M, Horiguchi J, Sato N, Kanatani K, Matsunaga K, Iwata H, Fujiwara Y

• 論文